16th-century murder mystery solved: Ancient DNA indicates Medici ruler ‘killed with arsenic’ may have died from malaria

Groundbreaking DNA evidence indicates that malaria might have caused the untimely deaths of Renaissance rulers Francesco I de’ Medici and Bianca Cappello. Researchers discovered the presence of lethal malaria parasites in their remains, which had been preserved for centuries. This revelation contradicts earlier beliefs of an assassination plot by Ferdinando, Francesco’s brother, suggesting instead that a mosquito-borne illness was behind their mysterious demise.

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